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Cyclophosphamide
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Cyclophosphamide

Cyclophosphamide is used alone or in combination with other medications to treat Hodgkin's lymphoma (Hodgkin's disease) and non-Hodgkin's lymphoma (types of cancer that begin in a type of white blood cells that normally fights infection); cutaneous T-cell lymphoma (CTCL, a group of cancers of the immune system that first appear as skin rashes); multiple myeloma (a type of cancer of the bone marrow); and certain types of leukemia (cancer of the white blood cells), including chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), acute myeloid leukemia (AML, ANLL), and acute lymphoblastic leukemia (ALL). It is also used to treat retinoblastoma (cancer in the eye), neuroblastoma (a cancer that begins in nerve cells and occurs mainly in children), ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed), and breast cancer. Cyclophosphamide is also used to treat nephrotic syndrome (a disease that is caused by damage to the kidneys) in children whose disease has not improved, has gotten worse, or has come back after taking other medications or in children who experienced intolerable side effects with other medications. Cyclophosphamide is in a class of medications called alkylating agents. When Cyclophosphamide is used to treat cancer, it works by slowing or stopping the growth of cancer cells in your body. When Cyclophosphamide is used to treat nephrotic syndrome, it works by suppressing your body's immune system.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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Cyclophosphamide injection comes as a powder to be added to fluid and injected intravenously (into a vein) by a doctor or nurse in a medical office or hospital outpatient clinic. It may also be injected intramuscularly (into a muscle), intraperitoneally (into the abdominal cavity), or intrapleurally (into the chest cavity). The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer or condition you have.

Your doctor may need to delay your treatment or adjust your dose if you experience certain side effects. It is important for you to tell your doctor how you are feeling during your treatment with cyclophosphamide injection.

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Combined effects of diltiazem and oxygen in pulmonary hypertension of mixed connective tissue disease. Among the components of the renin-angiotensin-aldosterone (RAAS) system, which controls blood pressure as well as fluid and electrolyte balance, renin, angiotensin II and its receptors AT1/2, and aldosterone and the mineralocorticoid receptor have been exploited as targets of drug development. 44 cases (48 eyes) with stromal disorder with normal endothelial function were treated by OFLK (25 eyes) or PKP (23 eyes).

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Using transcriptome profiling to characterize QTL regions on chicken chromosome 5. UVA-induced tumours in pigmented hairless mice and the carcinogenic risks of tanning with UVA. Integrated display of SPECT and MR brain images provides better localization of cerebral blood perfusion abnormalities in the peripheral cortex in relation to the anatomy of the brain than single-modality display and increases the confidence of the observer. In these studies, it could be shown that the replicative vector was capable of directing significantly elevated levels of reporter gene expression in myocytes compared to a non-replicative mRNA species.

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Management of neonatal massive anterior mediastinal teratoma--a case report. Polymorphisms in the Fas (FasR) and Fas ligand (FasL) genes have been reported to be associated with cervical cancer in certain populations. One of the three elements of the framework was facilitation, alongside the nature of evidence and context. Rising to the challenge of the new NCEP ATP III guidelines: exceeding current therapeutic limitations.

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Problem of an antagonist biological effect of ultraviolet and infrared rays Until a better technique is available the CIAP monitoring via the bladder or stomach should be considered as the standard for continuous monitoring of the IAP. Distorted local environment around Zn on Cu(2) sites in YBa2Cu3O7: An x-ray-absorption study.

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The structure of the conjugate of Bowman-Birk soybean proteinase inhibitor (BBI) with the block copolymer of ethylene oxide and propylene oxide (proxanol) containing five moles of proxanol per mole of protein, has been studied. Thus, very low friction values were measured as long as the supported layer(s) resisted the normal pressure of the tip. This paper presents the synthesis of hyperbranched polymers by the recently highlighted thiol-yne reaction. Observed differential responses prompted by folding preferences of the mimetics revealed stronger attachment activities for turnlike structures.

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According to the needs of clinical research, output pulse parameters of the cardiac stimulator can be designed. Aminosalicylate administration was withdrawn after the second visit.

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Renal impairment by the type of rapid-progressing nephritis with episodes of acute renal failure was the major sign in the clinical picture of those cases. Autologous placental blood transfusion after a planned neonatal pacemaker implantation. Role of the glutamic acid 54 residue in transthyretin stability and thyroxine binding. They further suggest that Zbtb20 plays a role in arealization of the midline cortex.

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In our opinion today primary velopharyngoplasty should be the exception. We discuss other mechanisms by which this species may maintain reproductive timing. Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutation. Study on the pharmacokinetics of Imipenem cilastatin in burn patients during the acute phase

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High-performance liquid chromatographic assay for the quantitation of nadolol in human plasma using fluorescence detection. This report presents the outcome of their discussions and highlights the key open questions that will help guide the field into a new era. The goal of this study was to utilize long-term patient follow-up to determine whether epithelial-to-mesenchymal transition (EMT)-related markers can predict bladder cancer patient survival and progression of disease.

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Diagnostic value of 64-slice CT angiography in coronary artery disease: a systematic review. The AL agent belongs to the unconventional viruses (prions) and causes degenerative changes in the CNS.

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There is a long way to go: a nationwide survey of professional training for mental health practitioners in China. Onset of diabetes modulates the airway smooth muscle reactivity of guinea pigs: role of epithelial mediators.

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The combination of BFM with colony probing allows the detection of B. Using the same database, these patients were compared with 268 patients undergoing TKA from January to December 2010 who also received multimodal analgesia but were not given pregabalin. The present study provided process documentation of two health education interventions which could be useful to both governmental and non-governmental organizations working in resource poor rural settings of developing countries.

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Special issue based on a symposium on Developmental Psychophysiology at the 7th International Congress of Psychophysiology of the International Organization of Psychophysiology. Significance of steroidogenic enzymes in the pathogenesis of hyperfunctioning and non-hyperfunctioning adrenal tumor. The present case represents the first report of the use of tissue expanders to treat dermal lymphatic malformations in the lower extremity and demonstrates a safe, staged approach to successful treatment. Lepidocephalus has been assumed to include only two species and confined to peninsular Malaysia and Indonesia.

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In addition, specific suggestions are provided for designing the transfer device to enhance patient comfort during the data transfer process and reduce deviation. Detrusor function during emptying is closely related to outflow conditions and therefore demands simultaneous registration of detrusor pressure and urinary flow rate. In conclusion, 3-BHA and BQ had an initiating activity in the cell transformation system and the potency of BQ was approximately 100 times higher than that of 3-BHA.

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The forensic identification of body fluids frequently presents an important source of genetic material and investigative interpretation. Results of a study on hormogerobion in the Municipal Home for the Aged at Offenbach-on-the-Main

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Back to basics in Africa: reflections on working with a palliative care team in rural Tanzania. It also provides myocardial viability data, prognostic information, and risk stratification before major cardiovascular and noncardiac surgery.

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Furthermore, PKC activation may be involved in the mechanisms of GJIC inhibition by inorganic arsenic. A mass spectrometer for rapid and continuous gas analysis in respiratory investigations.

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Injured dorsal root axons fail to regenerate into the adult spinal cord, leading to permanent sensory loss. The accuracy of SPECT with both presynaptic and postsynaptic tracers to differentiate between PD and APS is relatively low.

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Obstructive sleep apnea and hypopnea syndrome was diagnosed in all patients preoperatively. The purpose was to examine the medial wall of the articulatio humeri as well as the intraarticular position of the ligamentum glenohumerale mediale. Thus matching on the propensity score leads to unbiased estimators and tests of exposure effect. Furthermore, the feasibility of the technique was tested in 5 patients diagnosed with DVT by measuring the volume and T (1) values of the thrombus at 5 time points over a period of 6 months.

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We found 3 different haplotypes (TAGCT, TAGTT and TAGCC with frequencies of 0.66, 0.28 and 0.06, respectively) associated with the mutation in the 53 OCA2 patients, while 11 different haplotypes were observed in the control group. All participants were followed by phone over the subsequent 6 months.

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The structural and photocatalytic properties of ZnBiSbO4 had been characterized by X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, transmission electron microscope and UV-visible spectrometer. Although such variation may reflect divergent levels of predation, food availability or social stress in different environments, female competitive ability may also be balanced by significant reproductive costs and thus be subject to strong stabilizing selection. Dispersions of colloidal particles exhibit thermodynamic properties similar to those of molecular systems, including a hard sphere disorder-to-order transition. Problems in the estimation and utilization of genetic variability.

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Lysophosphatidic acid augments fibroblast-mediated contraction of released collagen gels. Differentiated practice: the new paradigm using a theoretical approach.

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We have used this technique for arthroscopic Bankart repair using suture anchor. The tumor was successfully removed by performing sleeve resection of the left main bronchus without pulmonary resection, immediately following which the left lung became reinflated.

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Recent work in ecology suggests that the diversity of responses to environmental change among species contributing to the same ecosystem function can strongly influence ecosystem resilience. In a previous work, we showed that dental pulp cells secrete soluble factors which interact with endothelial cells and affect the process of angiogenesis. Diabetic nephropathy (DN) is a major life-threatening complication of diabetes.

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An illustrative example of a regression approach to analysis of psychosocial moderator variables indicates both psychosocial measures, and symptom severity, independently contribute to the prediction of QOL in IBS. This study cohort comprised 205 T1D patients and 205 normal children. In short-term cultures, ESC proliferation in LBG coating was similar to ESC cultured in gelatin and the cells maintained their viability.

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In addition, the maintenance of the oral condition of the elderly is essential to enable them to stay healthy, especially to prevent aspiration pneumonia and improve mental health in an aging society. Subtype-specificity of the presynaptic alpha 2-adrenoceptors modulating hippocampal norepinephrine release in rat. Tandem mass spectrometry of nitric oxide and hydrogen sulfide releasing aspirins: a hint into activity behavior.

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Using high throughput, genetic, molecular and bioinformatics strategies, in combination with a systems biology approach, three transcriptional regulators of the pubertal process have been identified, and the structure of at least one hypothalamic gene network has been proposed. Perioperative outcomes including PSMs and major complications were unaffected by trainee involvement. its concentration in vesicles made of phosphatidylcholine, with variable acyl chain unsaturations. Both visual electrophysiological and retinometric detection, especially the latter one, can predict the post-operative visual acuity of the patients with partial opaque lenses accurately.

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The mechanism that renders patients with this syndrome susceptible to respiratory infections is not known. Comparison of transesophageal and intracardiac electrophysiologic studies in characterization of supraventricular tachycardia in pediatric patients. The attitudes of research ethics board (REB) chairs towards this practice, although integral to policy development, are unknown. Polypeptide growth factors in mammalian development: some issues for neurotoxicology and behavioral teratology.

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The regional cerebral blood flow was unchanged postoperatively in 19 patients, increased in 7 cases, and deteriorated in 6 patients. But the optimal treatment of massive PTE is controversial although various methods have been developed and improved. We investigated the effects of eye position on the response of sound-sensitive neurons in the SC of cats because previous work on cats and on monkeys had suggested the possibility of species differences in the representation of auditory signals in the SC.

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CVs of (PDDA/Hb)(n) films showed a pair of well-defined, nearly reversible peaks at about -0.34 V vs SCE at pH 7.0, characteristic of Hb heme Fe(III)/Fe(II) redox couple. This approach may have utility to inhibit platelet-rich thrombosis in injured and stenotic arteries where production of superoxide anion is increased.

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Human neutrophils express mRNA and protein for both a CTAP-III-like protein and hpa-1. Visual inspection in oral cancer screening in Cuba: a case-control study. Breast cancer risk after occupational solvent exposure: the influence of timing and setting.

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The development of an application for data privacy by applying an audit repository based on IHE ATNA. Minor surgery may have a small but significant influence on breathing and increased laryngeal resistance following endotracheal intubation may modulate these changes. The therapeutic options which are reviewed, including the use of somatostatin analogues, the role of surgery, the use of chemotherapy, biotherapy using interferon, peptide receptor targeted therapy. In this study, we used various inhibitors of metabolism, i.e., aminooxyacetate, oligomycin, and quinolinic acid, to examine the relation between this protective effect and the metabolism of L-alanine.

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The high intrinsic risk for lymphoproliferative disorder in the Epstein-Barr virus seronegative patient, which is amplified by higher levels of immunosuppression, may, in some instances, preclude transplantation. There is a high potential for topical and systemic use of Akacid as an antibiotic in humans individuelles lernen im sachunterricht strom und magnetismus grundschule and animals, in particular in cases of resistant microorganisms.

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Confidence between the patient and the surgeon remains the best guarantee of a good result of management. Patient characteristics and workflow processes associated with prolonged interval times and good clinical outcome (90-day modified Rankin score, 0-2) were analyzed. Neural sensing of electrical activity with losacor 50 mg roemmers stretchable microelectrode arrays.

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