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Adapin is a tricyclic antidepressant used to treat depression. It can also be applied on the skin to relieve itching associated with atopic dermatitis or lichen simplex chronicus. It may also be used as an analgesic for certain chronic and neuropathic pain and for anxiety.

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This medication is used to relieve troublesome itching from certain skin conditions (e. g. , atopic dermatitis, eczema, neurodermatitis). It should be used only for a short time (no more than 8 days). Adapin is a tricyclic antidepressant. It is not known how this medication decreases itching. Some medication is absorbed into the body when the cream is applied. This medication may work by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. The decrease in itching may be a result of drowsiness or some other effect in the brain that causes you not to notice or be bothered by the itching.

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