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We conclude that Alpam is capable of suppressing the primate pituitary-adrenal axis, and that this suppression most likely reflects suppression of the CRH neuron rather than of the pituitary corticotroph cell. The efficacy and safety of Alpam as compared to imipramine or a placebo added to weekly interpersonal psychotherapy was compared in a 6-week double-blind randomized clinical trial of 35 ambulatory elderly patients with major depression.

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Alpam is used to relieve symptoms of anxiety, including anxiety caused by depression. It is also used to treat panic disorder in some patients.

Alpam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Tablet
  • Tablet, Disintegrating
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Here we compare both response gains and neural detection thresholds of vestibular nuclei and semicircular canal afferent neurons in intact vs. In this study, we report a connection between the cytoplasmic domain of TANGO1 and SLY1, a protein that is required for membrane fusion. Ultrasound measurement of carotid plaque as a surrogate outcome for coronary artery disease.

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Separate sets of experiments then examined the effect of the co-administration of CGP56433A and baclofen on responding for cocaine or heroin under both schedules. The bead results correlated well with results using fluorescent lectin. Transforming growth factor-beta actions are mediated by binding to heteromeric complexes of type I and type II TGF-beta receptors.

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Bactericidal effect of doxycycline associated with lysosomotropic agents on Coxiella burnetii in P388D1 cells. These results suggest that participating in a class on the use of this leadership model may help leaders gain the skill needed to appropriately delegate decision-making to groups. The expression of fatty acid synthase (FAS), a key lipogenic enzyme and potential target for antineoplastic therapy, was analyzed in 87 frozen needle biopsies of prostate cancer using a highly sensitive immunohistochemical detection technique (Envision). The periodontal tissues--the PDL and alveolar bone in particular--become more flexible at the end of tooth movement, indicating reduced support by the periodontal tissues. The rate should be expressed as the number of deaths (numerator) over the number of procedures (denominator).

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Acid-fast bacilli were found in the granulomas and pulmonary tuberculosis was diagnosed. In the remaining 2 patients preexisting pathology in the posterior segment of the eye was strongly suspected. The high proliferation was associated with a low level of H2O2 related to a low SOD and a high PER activities. Flotation of the Bivalve Corbicula fluminea as a Means of Dispersal.

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Construction of a novel bovine papillomavirus vector without detectable transforming activity suitable for gene transfer. Furthermore, unlike the factor(s) found in vivo, the trophic activity of the conditioned medium was not enhanced by NGF and could be partially inhibited by mouse NGF antibodies. To determine the effects of itraconazole, a potent inhibitor of CYP3A4, on the pharmacokinetics of cerivastatin, a competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor. In this article, we focus on nanoparticles that have been functionalized by polymers. A new framework for a variational principle invokes a coercive form that results in a criterion for self-organizing relaxation of a two-fluid plasma.

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Different brain activation patterns during production of animals versus artefacts: a PET activation study on category-specific processing. The climacteric cross-culturally: the International Health Foundation South-east Asia study. This function bears upon two corner stones of social functioning, language and emotion, which have both been found to be impaired in schizophrenia.

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Although the sample size was small and our study could not determine which protocol element is essential for the neurological outcome, the findings suggest that clinical seizure control using midazolam without continuous electroencephalography monitoring or targeted temperature management is insufficient in preventing neurological damage in children with convulsive refractory febrile status epilepticus. When compared with the NEX method, the graphic method demonstrates a significant ability to more consistently and accurately determine the depth of pediatric gastric tube insertion. Increase in daily LH secretion in response to short-term calorie restriction in obese women with PCOS.

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Calorie restriction by either GB or VLCD lowered bile salt and FGF21 levels. Individual variation in line bisection: a study of normal subjects with application to the interpretation of visual neglect. However, a modicum of common sense must be employed in initiating their use. This technique was used to identify genes commonly overexpressed in breast and basal cell carcinomas. Gravitational field of a hedgehog and the evolution of vacuum bubbles.

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Leucine modulates contraction- and insulin-stimulated glucose transport and upstream signaling events in rat skeletal muscle. Baseline BPH Impact Index score, post-void residual urine volume, serum prostate-specific antigen (PSA) level, age, American Urological Association Symptom Index score, and maximum urinary flow rate were found to significantly correlate with overall BPH progression in multivariable analysis. Alcohol industry sponsorship and hazardous drinking in UK university students who play sport.

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Disorders of lymphocyte subpopulations counts and NK cells may not only contribute to impaired elimination of pathogens, but also be an important factor in the development of generalized inflammatory reaction. Danish biomedical research in the postgenomic era--who will take the initiative? Six h after UVB irradiation, there were no significant histologic differences between the hsp70.1(-/-) KO mouse and the wild type FVB mouse.

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Exposure to traumatic events is a highly prevalent, although often overlooked, aspect in the lives of homeless veterans. The objective of this study was to evaluate the therapeutic feasibility of a tissue engineering approach for prenatal coverage of MMC. Hypothyroidism due to pseudo-malabsorption of levothyroxine--Case 12/2009 Median time to TLSO arrival, start of PT, number of PT sessions, time to ambulate independently from admission, and length of stay (LOS). A flexible pressure monitoring system for pressure ulcer prevention.

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Genetic polymorphism A1675G on AT2R gene affects cardiovascular risk and the severity of atherosclerosis by modifying systemic inflammation, especially in hypertensive males. A sectional fixed appliance is described for the alignment of ectopic maxillary canines. For targeted plasma biomarker detection or untargeted plasma biomarker discovery, the challenges can be as difficult as identifying a needle in a haystack. Lymphoepithelial cyst of the pancreas is a rare but distinctive cystic lesion lined by a mature, keratinizing squamous epithelium and surrounded by lymphoid tissue.

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Metabonomics study of the effects of pretreatment with glycyrrhetinic acid on mesaconitine-induced toxicity in rats. Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells. The homes of 120 patients with asthma, 57 in Vancouver and 63 in Winnipeg, were studied. Lipid nanocapsules for transdermal delivery of ropivacaine: in vitro and in vivo evaluation.

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Effects of oral phytoextract intake on phenolic concentration and redox homeostasis in murine encephalic regions. Primary central nervous system cytotoxic T-cell lymphoma mimicking demyelinating disease. Dual promoter structure of mouse and human fatty acid translocase/CD36 genes and unique transcriptional activation by peroxisome proliferator-activated receptor alpha and gamma ligands. Although MSI is associated with specific clinicopathologic parameters, it did not predict overall survival in this group.

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With the less common genetic forms of CMT, identifying the causative genetic mutation by Sanger sequencing of individual genes can be time-consuming and costly. The developed convenient synthetic method is thus valuable not only to construct fluorescent probes and fluorescent bioactive compounds to gain information about target binding, but also from a structure activity point of view in the various areas where the phthalimides have displayed activity. The optic disc area was significantly (P less than 0.01) smaller than in 429 normal subjects and 556 glaucoma patients with high cup-to-disc ratios. Initial experience of two national centers in transcatheter aortic prosthesis implantation.

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