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Cycloxan (Cyclophosphamide)

Cycloxan is a cytotoxic (cytostatic), cell-cycle-nonspecific, antiproliferative agent that is used in such diverse medical problems as neoplasia, tissue transplantation, and inflammatory diseases. It is an inert prodrug for a potent nitrogen mustard alkylating agent. After the metabolic activation of Cycloxan to the potent mustard by liver enzymes, a nonenzymatic generation of chemically reactive molecules occurs. These reactive molecules can form covalent bonds with biologically ubiquitous groups, such as amino, phosphate, hydroxyl, carboxyl, sulfhydryl and imidazole, and as a result, depending on dose, Cycloxan is capable of either interfering with the reproduction of cells or killing cells. This is especially true in the case of rapidly dividing cells.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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Cycloxan is used to treat cancer of the ovaries, breast, blood and lymph system, and nerves (mainly in children). Cycloxan is also used for retinoblastoma (a type of eye cancer mainly in children), multiple myeloma (cancer in the bone marrow), and mycosis fungoides (tumors on the skin). It belongs to the group of cancer medicines called alkylating agents.

Cycloxan is also used for some kinds of kidney disease.

Cycloxan interferes with the growth of cancer cells, which are then destroyed by the body. Since the growth of normal body cells may also be affected by Cycloxan, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern. Some effects may not occur for months or years after the medicine is used.

Before you begin treatment with Cycloxan, you and your doctor should talk about the benefits of this medicine as well as the risks of using it.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Capsule
  • Powder for Solution
  • Tablet

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Inhibition of catalase in vitro by extracts of urine of normal and cancerous subjects B-1 cells are required for the secondary immune response and their role appears to be the production of IgM and not as a source of immunoregulatory molecules. To document the development of work participation in young adults with cerebral palsy who are transitioning into adulthood, examine associated characteristics, and investigate work limitations and barriers among employed persons. The work has been performed in healthy subjects and the authors studied, by cellular culture, flow cytometric analysis and ELISA assay, the expression of CD40 and PGE2 (prostaglandin E2) generation on gingival fibroblasts stimulated by beta-AR (beta-adrenoceptor) agonists.

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Determination of the potential for fundamental- and adjoint-representation sources in SU(2) in three dimensions. hUNC93B1: a novel human gene representing a new gene family and encoding an unc-93-like protein. To study possible alterations in mucin sulphation and mucin secretion, which could be the cause of decreased mucosal protection in ulcerative colitis. Theoretical models show that varying pulse duration influences residual thermal damage in erbium YAG skin resurfacing.

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LPO activation may contribute to maintenance of chronic renal inflammation in nephrolithiasis. Suppression of polarization fluctuations in chromium alloys with commensurate spin-density waves.

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Using conditioned media from OGD/R astrocytes with or without RNA interference for HMGB1, as well as with anti-HMGB1 antibodies, we evaluated the effect of astrocyte-derived HMGB1 on NS/PC proliferation. We showed that the absence of PSA or NCAM delayed migration of neural precursors to the olfactory bulb and consequently enhanced their recruitment at the lesion site.

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Autoradiographs of polyethylene spherulites containing low molecular weight tritiated polyethylene exhibited concentric ring patterns similar to those observed on viewing the polymer film in a polarizing microscope. To get complementary information from plasma samples, we used three different proteomic approaches, namely 2D-DIGE, SELDI-TOF-MS and 2D-LC-MS(E). Purification and characterization of membrane-bound hydrogenase from a thermophilic hydrogen-oxidizing bacterium, Pseudomonas hydrogenothermophila strain TH-1.

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Self-report measures predict variance in functional outcome beyond measures of clinical symptomatology and neuropsychological impairment. These data suggest that DRA is the major apical anion exchanger in the duodenum as well as the colon and the likely transport protein for duodenal electroneutral HCO3- secretion. The reflex sympathetic dystrophy syndrome associated with breast cancer Traditional therapy did not appreciably change the level of phagocytosis. Specific hybridization was found with oligonucleotide probes for mRNA encoding alpha 1, alpha 2, alpha 3, beta 1 isoforms of the Na, K-ATPase.

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Sudden death in Unverricht-Lundborg patients: is serotonin the key? The human transferrin receptor (TfR) contains three N-linked oligosaccharides and glycosylation is required for the proper folding and function of the molecule.

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Modeling radioprotective mechanisms in the dose effect relation at low doses and low dose rates of ionizing radiation. The study of randomness in low-dimensional quantum antiferromagnets is at the forefront of research in the field of strongly correlated electron systems, yet there have been relatively few experimental model systems.

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Three different pore size ranges of cross-linked alginate hydrogels were fabricated. Transfection of PCR products containing the mutant HBV sequences resulted in increased amounts of intracellular replicative intermediates but the decreased secretion of HBsAg and HBeAg into culture media, suggesting accumulation of nonenveloped viral core particles within the cells. To observe the distinctive pathomorphological features of sarcomatoid carcinoma (SC) in mammary gland as well as its diagnosis and differential diagnosis.

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The apoptosis-inducing effect of noradrenaline was mimicked by isoproterenol and blocked by propranolol, which indicates that noradrenaline triggers apoptosis via a beta-adrenergic signaling pathway. New atrial fibrillation classification by electrocardiogram will help general practitioners deliver personalized treatment. Use of the oral diuretics, aminometradine and aminoisometradine, in the sodium and water retention of hepatic cirrhosis.

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Sequential dose-dense 5-fluorouracil, epirubicin and cyclophosphamide followed by docetaxel in patients with early breast cancer with four or more positive lymph nodes. Practice variation in gastroschisis: factors influencing closure technique. She was treated with oral albendazole and topical crotamiton with salicylic acid 5 percent. We also describe the complementary nature of the fields of population genomics and molecular plant-microbe interactions and propose how to translate new insights into improved disease prevention and control. This study is aimed at knowing the results of donor hepatectomies at our centre.

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Achieving acceptable air quality: some reflections on controlling vehicle emissions. coli to buccal cells at drug MICs of 1/2 to 1/32 and 1/2 to 1/64, respectively. Age younger than 35 years has been used as a factor in identifying young adult chronic mentally ill patients, a group considered difficult to treat due to their rebelliousness, lack of insight about their mental illness, and increased likelihood of showing symptoms of borderline or antisocial personality disorder. Federal Pay: In the Competition for Professionals, Government Faces Salary Gap, Other Problems. Proposed classification of longitudinal melanonychia based on clinical and dermoscopic criteria.

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To analyze survival and recurrence in patients with extremity soft tissue sarcoma who survive for more than 5 years. Research into and development of a best model for effective interdisciplinary work are needed.

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Initially, the system used the traditional gamma in air irradiation sterilization method, but was transitioned to Gas plasma sterilization. Predictive value of tetrapolar body impedance measurements for hydration status in critically ill patients.

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Restorative proctocolectomy with ileal pouch-anal anastomosis has become the surgical treatment of choice for most patients with ulcerative colitis who require surgery. Multi-modality in management of primary malignant non-Hodgkin lymphomas of the central nervous system. Furthermore, results from numerous investigations are presented, including our own findings on these pathological conditions, as well as the techniques applied for their evaluation. To specifically address the relative pre- and postsynaptic contribution to spinal opioid analgesia, we have quantitatively assessed the pre- vs. For functional assessment of the parotid glands, we conducted the Saxon test and used a visual analog scale (VAS) for xerostomia evaluation.

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Thus some kinds of lichens may be absent from city environments because of atmospheric pollutants which destroy chlorophyll. Feulgen-DNA content, nuclear phenotypes, and levels of chromatin condensation were evaluated by image analysis in NIH/3T3 cells transformed with the c-H-ras oncogene of T24 cells. Future research is required to accurately define vaginal dose distribution to study its correlation with vaginal morbidity. Intracellular induction of Listeria monocytogenes actA expression. Some biochemical characteristics of hydrochloric-acid injury of the cornea.

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The relationship between knowledge and clinical performance in novice and experienced critical care nurses. The Low Contact Stress (LCS) Total Knee System (DePuy Orthopaedics Inc, Warsaw, Ind), a mobile-bearing knee arthroplasty design, was introduced in 1977. Study of the comparative action of corn oil and butter in experimental dyslipoidosis in rats This situation places them in a position to influence life-styles. Biobank policy and regulations profoundly vary between different societies.

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INCENP-aurora B interactions modulate kinase activity and chromosome passenger complex localization. Virus infection and inflammation alter protein N-glycosylation, and we have previously shown that changes in cellular N-glycosylation are involved in regulation of NKG2D ligand surface expression. The delay in diagnosis averaged four years with the most common mistaken diagnosis being cervical disc disease. Overall, our results demonstrate that binge ethanol exposure during puberty changes the central expression of stress-related genes in a sex-specific manner, potentially leading to permanent dysregulation of the HPA axis and long-term behavioral consequences. Sequence conservation and direct experimental evidence have implicated sequences within and between the HS cores in function of the LCR.

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New information-based approaches could yield better homeland protection. Sokal of the porque han retirado junifen dosage State University of New York at Stony Brook unveiled a beta-test microcomputer version of their phenetic program package, NT-SYS. Transesophageal echocardiography combined with magnetic resonance imaging for detecting venous anomalies in dextrocardia. This mechanism includes a classical activator-inhibitor system, but is based on the modifications of the membrane structure, rather than a reaction-diffusion system. Determinations of breakpoints require tools such as the understanding of dosing, MIC distributions of organisms without resistance mechanisms, pharmacokinetics, pharmacodynamics, and of clinical outcome in defined clinical situations.

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One month later, complete occlusion of the left internal carotid artery was shown angiographically. Prophylactic zidovudine clopidogrel 75 mg oral tablet for a child after human immunodeficiency virus needlestick exposure. Minor ossicular anomalies in the middle ear: role of submillimeter multislice computed tomography. Practical significance of measuring high formant spectra in phoniatric voice assessment

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After the surgery, the patients were trained for synchronous contraction of the trapezius and diaphragm muscles, and electromyography (EMG) was performed to evaluate the synchronization. Early and delayed cardiac mortality after acute myocardial infarction in the pre-thrombolytic era. Furthermore, the development of adipocytes in the hostacycline tetracycline hydrochloride dose skin is independent from that of subcutaneous adipose tissue development. To study the effect of peri-implantitis inflammatory microenvironment on the biological function of jaw bone osteoblasts. Transitions in caregiving: evaluating a person-centered approach to supporting family caregivers in the community.

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HTLV-I viral-associated myelopathy after blood jill magid becoming tarden medicine transfusion in a multiple trauma patient. Epstein-Barr virus-associated typical gastric carcinoma detected by in situ hybridization and polymerase chain reaction. Subluxation of the inferior radio-ulnar joint complicating fracture of the radial head. Drag reducing polymers improve coronary flow reserve through modulation of capillary resistance.