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Niar (Selegiline)

Switching from amoxapine 150 mg/day to Niar 7.5 mg/day, a selective monoamine oxidase type-B inhibitor, produced a dramatic reduction in hypobulia and lassitude, leading to a complete remission of all depressive symptoms. CYP2C19 polymorphism does not seem to be crucial for the metabolism or clinical effects of Niar.

Other names for this medication:
Selegiline, Eldepryl, Anipryl, Carbex, Comenter, Deprenyl, Jumex, Niar, Segan, Selecom, Selegilina, Selegos, Selerin, Selgene, Selgian, Selgin, Selgina, Zelapar,

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Niar comes as a capsule and an orally disintegrating (dissolving) tablet to take by mouth. The capsule is usually taken twice a day with breakfast and with lunch. The orally disintegrating tablet is usually taken once a day before breakfast without food, water, or other liquids. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Niar exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. If you take too much Niar, you may experience a sudden and dangerous increase in your blood pressure.

If you are taking the orally disintegrating tablet, do not remove the blister that contains the tablets from the outer pouch until you are ready to take a dose. When it is time for your dose, remove the blister card from the outer pouch and use dry hands to peel open one blister. Do not try to push the tablet through the foil. Place the tablet on your tongue and wait for it to dissolve. Do not swallow the tablet. Do not eat or drink anything for 5 minutes before you take the tablet and for 5 minutes after you take the tablet.

If you are taking the orally disintegrating tablet, your doctor may start you on a low dose of Niar and increase your dose after six weeks.

Tell your doctor if you experience nausea, stomach pain, or dizziness. Your doctor may decrease your dose of levodopa/carbidopa during your treatment with Niar, especially if you experience these symptoms or other unusual symptoms. Follow these directions carefully and ask your doctor or pharmacist if you do not know how much medication you should take. Do not change the doses of any of your medications unless your doctor tells you that you should.

Niar may help to control the symptoms of PD, but it will not cure the condition. Do not stop taking Niar without talking with your doctor. If you suddenly stop taking medications for Parkinson's disease such as Niar, you may experience fever, sweating, stiff muscles, and loss of consciousness. Call your doctor if you experience these or other unusual symptoms after you stop taking Niar.

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