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Topiramate
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Topiramate

Topiramate is a medicine called an anticonvulsant. It is used to control and prevent certain types of seizures. It is often used to control and prevent tonic-clonic seizures, also called grand mal seizures. It may also be used to treat partial seizures. You may also hear Topiramate called by one of its brand names, Topiramate.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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Topiramate is used alone or with other medications to treat certain types of seizures including primary generalized tonic-clonic seizures (formerly known as a grand mal seizure; seizure that involves the entire body) and partial onset seizures (seizures that involve only one part of the brain). Topiramate is also used with other medications to control seizures in people who have Lennox-Gastaut syndrome (a disorder that causes seizures and developmental delays). Topiramate is also used to prevent migraine headaches but not to relieve the pain of migraine headaches when they occur. Topiramate is in a class of medications called anticonvulsants. It works by decreasing abnormal excitement in the brain.

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Stereotactic radiation therapy (SRT) of brain metastases is used with good effect around the world, but no consensus exists regarding which prognostic factors that are related to favourable or unfavourable prognosis after the treatment. In addition, comparison studies of two different pre-treatment approaches as well as the two ionization modes were conducted. The single-gene network architecture was also effective in buffering against transcriptional noise, leading to reduced cell-to-cell variability in protein synthesis.

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In the immediate postoperative course, the patient developed a progressive decrease in the right eye visual acuity. These results together indicate that Edg isoform-specific, negative or positive regulation of cellular Rac activity is critically involved in S1P-mediated bimodal regulation of cell motility in SMCs and HUVECs.

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In this review, we present an overview on the role of miRNAs in resistance mechanisms of NSCLC, discussing the main studies on the aberrations in apoptosis, cell cycle and DNA damage repair pathways, as well as in novel drug targets. The study was conducted among patients enrolled in an egg-donation program. All 20 parameters of morphological criteria had practical significance in pathologic diagnosis, the most significant ones being architectural changes, prominent nucleoli, perineural and stromal invasion.

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However, if chest pains do occur, measures such as airway management, oxygen supplementation, coronary artery dilation, analgesis and in extreme cases, cardiopulmonary resuscitation and evacuation to the emergency room, may be necessary. Disulfide bond formation and folding of plant peroxidases expressed as inclusion body protein in Escherichia coli thioredoxin reductase negative strains. Phl p 5, a major grass pollen allergen, contains several T-cell epitopes. Mrj encodes a DnaJ-related co-chaperone that is essential for murine placental development.

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The study findings suggest that Pittsburgh insomnia rating scale has excellent internal consistency, test-retest reliability and good validity for university population of poor sleepers in India. Conversion efficiency of skutterudite-based thermoelectric modules. Suppression of the observation of Stark ladders in optical measurements on superlattices by excitonic effects. Isolated lymph node metastasis in pericardial fat flap after bronchial stump coverage

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Planar polarity in mammals: similarity and divergence with Drosophila Melanosgaster To provide an overview of common challenges that pediatric eHealth researchers may encounter when planning, developing, testing, and disseminating eHealth interventions along with proposed solutions for addressing these challenges. Clinical and histopathological data of all cases were reviewed and correlated. We show that prediction of functional TF targets from ChIP-chip data can be improved by using the conservation of STAP predicted affinities as an additional filter.

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These treatment strategies have provided some relief, which is usually less than satisfactory within a short period of time. The experimental and theoretical results for the dibenzoacenes are also compared with those for the polyacenes. These patients maintain the same level of cognitive and neurologic function and MR findings do not correlate with the results of cognitive testing. Duplex sonography accurately predicts shunt patency and dysfunction when compared with portal venography. The interpretation of P-values and the combination of test results.

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The appropriateness of relying on the coefficient of determination (r(2)) as a statistical metric for judging the predictability of human clearance (CL) based on interspecies animal data was assessed. Osteoporosis-related fractures increase mortality and reduce quality of life.

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Nicotine promotes late endothelial progenitor cells functional activity in a PI 3-kinase-dependent manner. We sought to describe uptake of Tdap and identify predictors of vaccination in pregnancy. Practical value of applying cdc2 kinase shRNA to chronic proliferative cholangitis in treatment of hepatolithiasis.

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Autocrine induction of the metastatic phenotype was demonstrated in NIH-3T3 cells transformed by a signal peptide-bFGF gene but not bFGF in the absence of the signal peptide. To determine if clinical variables assessed in relation to Albuterol aerosol treatments accurately identify children with pathologic radiographs during their initial episode of bronchospasm. FLUKA is an integrated particle transport code that has enhanced multigroup low-energy neutron transport capability similar to the well-known MORSE transport code. Patients with anterior spaces caused by periodontal disease treated with aligner technique

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Recent data suggest that neonatal diabetes is more common than previously thought, with variable presentations. Investigation of the molecular mechanism of action of molsidomine/SIN-1 indicate that molecular oxygen initiates NO formation through a one-electron abstraction from the intermediate.

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Genomic DNA was extracted from the peripheral blood of 110 relatives, and hybridized to Affymetrix SNP arrays. Anterior cruciate ligament reconstruction using quadriceps tendon autograft: intermediate-term outcome.

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Unlike conjugative plasmids that are extra-chromosomal and replicate autonomously, ICEs are integrated in the chromosome and replicate passively during chromosomal replication. This is the second of a series of three articles relating to oral care for older people. Depletion of cortical cholecystokinin levels after excitotoxin injection into the nucleus basalis: sensitivity to MK-801. Our standard anticoagulant is unfractionated heparin, where the primary mode of action is potentiation of endogenous AT-III.

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The number of women in the United States giving birth via cesarean remains high as the number of vaginal births after cesarean (VBAC) declines. The supported tools include: baskets, graspers, intracorporal lithotripters, guidewires, catheters, stents, biopsy and dilatation devices. Heart rate and blood pressures correlated significantly between all four laboratory tasks for both absolute levels and reactivity scores (calculated as task level minus pre-task baseline level).

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Transcriptomes were assembled and compared on the basis of the presence of signal, rank-order gene expression, and pathway enrichment using Ingenuity Pathway Analysis (IPA). Orbitofrontal Cortex Reactivity to Angry Facial Expression in a Social Interaction Correlates with Aggressive Behavior. A 14-year-old boy had suffered from progressive infiltrative erythema and plaques that gradually evolved into lax masses and pendulous skin on his axilla, anterior wall of the abdomen, bilateral inguinal region, and thighs. Studies on treatment programs under controlled conditions are few and incomplete. Severe acute exposures to carbon monoxide caused foetal death or toxic effects, including anatomical malformations and functional alterations.

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To explore the existence of natural foci on Marmota himalayana plague in Sichuan province and to provide basis for prevention and control of the disease. The proliferation marker thymidine kinase 1 level is high in normal kidney tubule cells compared to other normal and malignant renal cells. Since the introduction of surgical procedures such as the intra-auricular reorientation of the venous return (Mustard procedure), an increasing number of patients may reach adulthood and experience pregnancy. Remote artificial eyes using micro-optical circuit for long-distance 3D imaging perception. Most of the volcanics were erupted about 4500 years ago and overlie a regionally extensive paleosol which developed largely during the last glaciation.

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Bronchiectasis and homozygous (P1ZZ) alpha 1-antitrypsin deficiency in a young man. The mechanisms of high-phosphate-induced vascular calcification in patients with chronic kidney disease To test the generality of hypotheses on birdsong, we investigated female song in the sex-role reversed, classically polyandrous African black coucal (Centropus grillii) in the context of female-female competition. It has been demonstrated to be transiently expressed in preovulatory follicles and to positively affect several parameters correlated with the ovulatory process. Here, we report that NMD, like the DDR, affects single-stranded DNA (ssDNA) production at uncapped telomeres.

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There is therefore a need for new or supplementary markers to improve the treatment. We tested the efficacy of DOX in the breast cancer cell line MCF-7/MDR1 and in a MCF-7/MDR1 xenograft nude mouse model using the MSNs drug delivery system. We measured insulin-like growth factor-1, prolactin, luteinizing hormone, follicle stimulating hormone, thyroid function, oestradiol or testosterone and cortisol levels following a short synacthen test.

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This phase I dose-escalation study was designed to determine the maximum tolerated dose (MTD) and recommended dose of cetuximab administered on an every-second-week schedule to patients with metastatic colorectal cancer, on the basis of safety, pharmacokinetic and pharmacodynamic evaluation. Evidence about harm may come not only from randomised trials but also from other sources. Complications in cosmetic laser and energy based surgery affect a number of patients every year and may cause scars, burns, blisters, and pigmentation damage. A strategy for minimizing the effect of misclassifications during real time pattern recognition myoelectric control.

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A BUBBLER PUMP METHOD FOR QUANTITATIVE ESTIMATIONS OF BACTERIA IN THE AIR. It has been suggested that markers associated with cancer stem cells (CSC) may play a role in esophageal cancer.

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It has long been known that processes occurring within a species may impact the interactions between species. Laparoscopic lateral partial adrenalectomy is a technically challenging tissue-sparing operation.

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Rates of lung cancer in Hispanics were approximately half of those observed for non-Hispanic whites. NPCs engrafted into spinal cords of JHMV-infected mice exhibited diminished migration velocities and increased proliferation compared with transplanted cells in noninfected mice. The cutaneous circulation is influenced by a variety of thermoregulatory (skin and internal temperature-driven) and nonthermoregulatory (e.g., baroreflex, exercise-associated reflexes) challenges. Magnetic labels can be detected by a wide range of non-invasive methods, are physically and chemically stable, relatively inexpensive to produce, and can be easily made biocompatible.

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In the current investigation, we turned our attention to the analytical characterization of diffusion through cell membrane compartments having both a uniform size and permeability. After an initial discussion group to assess cultural acceptability of the project, 6 focus groups were conducted with 33 KPCO African-American members. The four stages preceding the postconventional level in the Kohlberg (1958, 1971, 1976) system of moral development are described as involving moral judgments that conform to external conditions of punishment, reward, social expectation, and conformity to the law. Just how close are we to solving the obstacles in the way of successful gene implantation / replacement?

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Electronic organization of patient records as a component of integrated medical informatics Compound 4b promises to be a potentially useful antimicrobial agent for vancomycin-susceptible and -resistant enterococci. Multiple resistances and complex mechanisms of Anopheles sinensis mosquito: a major obstacle to mosquito-borne diseases control and elimination in China.

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We propose that minimally invasive spinal surgery can achieve good outcomes, low complication rates and high rates of satisfaction. Six had a point mutation in the preC region prohibiting the encoding of HBeAg precursor, while the remaining two had a deletion of 8 or 21 nucleotides within the X gene upstream of the preC transcription initiation sites which would affect the X gene and the putative preC/C promoter.

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Moreover, both midfacial tissue and the papillae maintained the early increase recorded before the first year of the follow-up. We report the deposition of uniform porous MnO2 nanowalls on a conducting carbon fiber substrate using a simple electrochemical method, which produces ordered nano-channels demarcated by the MnO2 walls for easy ion transport and a continuous electron path created by the carbon backbone. Magnesium-iron replacement in clay minerals in anoxic marine sediments. These data imply that TNF may inhibit the cell cycle in hematopoietic progenitor cell populations. We report a 52-year-old male who developed focal, chronic persistent measles virus infection of the brain following interferon and ribavirin therapy for hepatitis C, and who responded to steroid therapy.

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Combination of these two chromatographic procedures yields maximum information on primary structure of the oligonucleotides. In comparison, cortisol increased ERP voltage between 500 and 1400 ms post-stimulus and this effect interacted with item type and electrode site, being diffusely distributed for correct rejections but of a lesser magnitude frontally for old items accorded a correct source judgement. Parental perceptions of barriers to physical activity in children with developmental disabilities living in Trinidad and Tobago. Fluid and electrolyte changes of thyroidectomized rats in a cold environment. Combined imaging approach to diagnose a meningioma in a patient with prostate and lung cancers.

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Dissipationless clustering of neutrinos in cosmic-string-induced wakes. These preliminary results suggest that neonatal hormonal and metabolic responses to cardiac surgical operations in neonates are extreme and are associated with a high hospital mortality rate. Bovicin HJ50-like lantibiotics, a novel subgroup of lantibiotics featured by an indispensable disulfide bridge.

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They no longer responded to erythropoietin, failed to express an erythroid-specific surface antigen, and ceased producing transcripts for globin genes, GATA-1 and SCL. Role of the VirA histidine autokinase of Agrobacterium tumefaciens in the initial steps of pathogenesis. Various types of RP complex with different subunit compositions are present in rice cells, suggesting the multiple functions of rice proteasome. However, brain levels were generally lower than those in non-neural tissues. Integrated management of the HIV positive patient--medical, psychological and psychosocial aspects

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Transcomplementation of M-deficient RABV with M from European bat lyssavirus (EBLV) types 1 and 2 reduced the release of infectious virus. Thus, the specific defects in spermiogenesis in RARalpha-deficient testes may correlate with a disrupted cyclic expression of RA-responsive structural components, including vimentin, a downregulation of connexin-40 in spermatogenic cells, and delayed assembly of ZO-1 into Sertoli cell tight junctions. In cluster analysis for a limited number of residues at the binding pocket, crystal structures were not distinctly separated, and no clear factor linked to the separation was clarified. The aim of this study was to examine, in a prospective fashion, the predictive value of osteitis on the pre-operative CT scan of the paranasal sinuses at correctly identifying the site of attachment of sinonasal inverted papilloma. It is shown that compatible QD-immunobuffer systems can be used to achieve a higher assay signal/background ratio.

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Positive feedback regulation in mitotic conditions is suggested by the observation that overexpression of Ime1p leads to increased levels of IME1-lacZ. 17 allograft recipients were immunosuppressed with cyclosporine A (CsA). m-calpain can be easily distinguished from mu-calpain due to its higher mobility in the gel. Although this molecule may have limited use pharmacologically, it may serve as an important template for the development of new GLO1 inhibitors that may combine this strategy with ones already reported for high affinity GLO1 inhibitors, potentially improving potency and specificity.

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As the proliferation of stroma, the infiltration of eosinophils was seen in the perigrandular stroma that consisted of rich collagen. The aim of this study was to investigate the effect of endoscopic variceal band ligation on hemorrhoids, anorectal/colonic varices and portal hypertensive colopathy. Tumorigenesis may be an aberrant consequence of the molecular mechanisms needed to maintain this pattern of viral growth regulation in the context of the cell cycle. To determine the correlation between symptoms and signs of disease activity in BCR and specific findings on OCT-EDI. The survey assessed the prices and availability of essential medicines using the World Health Organization and Health Action International methodology.

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Five patients had already progressed to chronic renal failure at the time of scintigraphy. Induction of ResDE-dependent gene expression in Bacillus subtilis in response to nitric oxide and nitrosative stress. Cell proliferation following non-thermal plasma is related to reactive oxygen species induced fibroblast growth factor-2 release.

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Opsonic activity in cord blood: comparison between normal and elevated immunoglobulin M infants. The dosimetry calculations use a combination of in vivo uptake and biodistribution data from one rhesus monkey and seven humans to estimate residence times in eight organs. We suggest that endometrial carcinoma remains a differential diagnosis of any pelvic or abdominal mass even after hysterectomy, and a history of intake of oestrogen agonists and antagonists needs to be obtained. Ductions: OS pironal forte bagoys abolished adduction, limitation of depression, OD normal.

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Psychological stress in undergraduate dental students: baseline results from seven European dental schools. Space-occupying lesion was found by head symptoms of over using ibuprofen in rotator computer tomography in the left brain hemisphere of the patients with lung and lymph node sarcoidosis. Records of birth weight and prematurity in the Wasukuma of Lake Province, Tanganyika. Free radicals initiate peroxidation reactions by hydrogen abstraction from methylene groups adjacent to double bonds of fatty acids and lipids within cellular membranes. Quantum theory of infrared absorption in a grating-coupled two-dimensional electron gas.

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In a first screening step the supernatants of the 297 emerging hybridomas were immunocytochemically tested on sections of the CNS of L. Here, we ramoclav 875/125 pills show that this element not only is bound by Tst-1/Oct-6 but, in addition, serves as a binding site for the high-mobility-group protein HMG-I/Y. When keratinocytes were grown on these dermal equivalents they produced a very severe contraction, to an extent that all skin equivalents had a similar final surface area. Computer simulations of dynamics of flux lines in type-II superconductors.

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Expansin and expansin-related proteins loosen plant cell wall architectures and lofentanil lethal dose of clonazepam are widely distributed in several types of organisms, including plants, fungi and bacteria. Case of autoimmune progesterone dermatitis presenting as fixed drug eruption. New Zealand White rabbits that received intra-articular injections of Ad.RSVIL-1ra expressed transgenic IL-1ra in synoviocytes, and secretion was detected for at least 4 weeks post-infection.